Intrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma and Hepatocellular Carcinoma Histopathology Reporting Guide
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HISTOLOGICAL TUMOUR TYPE (Note 7) Hepatocellular carcinoma Hepatocellular carcinoma, fibrolamellar variant Cholangiocarcinoma Combined hepatocellular – cholangiocarcinoma Intraductal papillary neoplasm with an associated invasive carcinoma Mucinous cystic neoplasm with an associated invasive carcinoma Undifferentiated carcinoma Carcinoma, type cannot be determined mm Intrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma and Hepatocellular Carcinoma Histopathology Reporting Guide
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Cholangiocarcinoma
Cholangiocarcinoma represents a diverse group of epithelial cancers united by late diagnosis and poor outcomes. Specific diagnostic and therapeutic approaches are undertaken for cholangiocarcinomas of different anatomical locations (intrahepatic, perihilar, and distal). Mixed hepatocellular cholangiocarcinomas have emerged as a distinct subtype of primary liver cancer. Clinicians need to be awa...
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Cholangiocarcinoma (CC) is divided into distal, perihilar, and intrahepatic CCs (ICCS), and are further subdivided into large bile duct ICC and peripheral ICC. In distal and perihilar CC and large duct ICC, biliary intraepithelial neoplasm (BilIN) and intraductal papillary neoplasm (IPN) have been proposed as precursor lesions. Peripheral ICC, bile duct adenoma (BDA), biliary adenofibroma (BAF)...
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Cholangiocarcinoma arising in the liver can be classified into intrahepatic (or peripheral) cholangiocarcinoma (ICC) or perihilar cholangiocarcinoma, depending on the topographic location of the tumor along the intrahepatic biliary tree. Grossly, peripheral ICC usually presents as a mass-forming type, while perihilar ICC may present as mass-forming, periductal infiltrating, or intraductal-growt...
متن کاملWhat is the current state-of-the-art imaging for detection and staging of cholangiocarcinoma?
Cholangiocarcinoma is an adenocarcinoma that arises from the bile duct epithelium and is the second most common primary hepatobiliary cancer, after hepatocellular cancer, with approximately 2,500 cases annually in the U.S. However, cholangiocarcinoma remains a relatively rare disease, accounting for <2% of all human malignancies. Although the entire biliary tree is potentially at risk, tumors i...
متن کاملDifferent roles of S100P overexpression in intrahepatic cholangiocarcinoma; Carcinogenesis of perihilar type and aggressive behavior of peripheral type Running title: S100P expression in intrahepatic cholangiocarcinoma
S100P is expressed in several kinds of malignant tumors. Intracellular S100P interacts with ezrin, and extracellular S100P activates the receptor for advanced glycation end-products (RAGE). However, little is known about the biological significance of S100P and related protein in cholangiocarcinoma. Biliary intraepithelial neoplasia (BilIN) is a precursor lesion of hilar or perihilar cholangioc...
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